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KMID : 1007020050030010046
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Korean Soceity of Osteroporosis
2005 Volume.3 No. 1 p.46 ~ p.53
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Association Study of the Relationship Between Polymorphism of the Interleukin-6 Gene and Bone Mineral Density in Premenopausal Korean Women
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Lee Yu-Sun
Park Se-Na
Lee Ji-Young
Lee Woon-Jung
Hur Sung-Eun
Chung Hye-Won
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Abstract
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Objectives: To investigate a possible relationship between single nucleotide polymorphism of human IL-6 promoter －572 locus and peak BMD of Korean women.
Method: We examined BMD of 477 premenopausal Korean women(by peripheral DEXA) and extracted DNAs from peripheral blood samples. Polymerase chain reaction was used to detect IL-6 gene polymorphism.
Results: The mean age, height, and weight of patients were respectively 37.89±6.84 years, 158.70±4.81cm, and 56.94±7.34kg. They were not significantly different(P＞0.05). The genotype distribution was as follows; GG genotype, 263(55.1%) women; GC genotype, 186(40.0%) women; CC genotype, 28(5.9%) women. BMDs of forearm in genotype GG, GC, CC were 0.56±0.17g/cm2, 0.59±0.19g/cm2, 0.58±0.19g/cm2, respectively. They were not significantly different(P＞0.05). BMDs of calcaneus were 0.47±0.09g/cm2, 0.47±0.10g/cm2, 0.46±0.11g/cm2, respectively. There was no statistical significance in BMD in each genotypes(P＞0.05).
Conclusion: We concluded that IL-6 -572 SNP have no correlation with BMD of premenopausal Korean women. IL-6 promoter -572 SNP would not be a genetic factor of premenopausal bone mineral density.
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KEYWORD
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Interleukin-6, Bone Mineral Density, SNP, Premenopause
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